Intra-renal and Urinary Oxygenation during Resuscitation with Norepinephrine and Angiotensin II in Ovine Acute Kidney Injury

Abstract

Background and Aims Acute kidney Injury (AKI) is a common phenotype of sepsis leading to high mortality rates. Norepinephrine (NE) is the first choice vasopressor used clinically to restore blood pressure and renal function, whilst there is emerging interest in angiotensin II (Ang II) as an effective adjunctive therapy in patients with septic shock. Increasing evidence suggests that hypoxia in the renal medulla may play a critical role in the pathogenesis of AKI. We therefore measured renal cortical and medullary tissue oxygen tension (PO 2 ) in conscious sheep during development of septic AKI and followin..